How Can You Manage a Dry Nose or Nosebleeds on Accutane?

For dryness, add moisture without irritating your nose

Dryness and nosebleeds are both reported with oral isotretinoin. For mild dryness, try a moisturizing nasal spray and avoid picking, rubbing, or forceful blowing.

A tiny amount of petroleum jelly just inside the nostril is another option described in dermatology guidance, but do not snort or inhale it.

How to handle an active nosebleed

Sit down and lean forward so you are less likely to swallow blood. Pinch the soft part of the nose closed between your thumb and finger for a full 10 minutes without releasing the pressure to check early. Breathe through your mouth.

When a nosebleed is urgent

Get emergency care if bleeding has not stopped after 20 minutes.

If nosebleeds keep happening

Tell the isotretinoin prescriber if nosebleeds recur so they can review dryness care and your treatment. Do not change or interrupt isotretinoin on your own.

For broader care of treatment-related dryness, see the gentle Accutane skincare routine.